tlr1616 TILS_THEEB 344 tRNA(Ile)-lysidine synthase tRNA(Ile)-lysidine synthetase tRNA(Ile)-2-lysyl-cytidine synthase MWGIHHARLHTTLKTQQWLPLGSRILIALSGGQDSVCLTRLLLDLQPHWQWSLVAVHCDHRWRADSTANANFVQQLAQKWHLPCEVVSAPDLPKTEAAARSWRYQVFESVAKALDCTHVVTAHTQSDRAESLLLHLLRGTSPDGLATLLPSRSLGAIQLVRPLLGMTRAQTAAFCQAYGLPIWQDETNHNLEYRRNRLRLELIPYLQQHFNPNVEEALAQTAELLASDRAYFEAEVERLAPTVLREHPPALDRLRLREFPLALQRRLIQCFLRQHLKRGLNFRVIEAVRALMTTGNGSQTASLPGGQHLRVCGRWIELVRPMPPPPAPVPPDPGERSPPPSPLY tilS Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity).